Age-associated alterations of the neuromuscular junction
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چکیده
منابع مشابه
Neostigmine-induced alterations at the mammalian neuromuscular junction. II. Ultrastructure.
Brief and chronic exposure of rats to neostigmine methylsulfate produced marked morphological alterations of the fine structure at the end-plate region of the extensor digitorum longus muscles. These changes were dose and time dependent and were restricted primarily to the subjunctional myofibrillar apparatus and membrane-bound organelles. In addition, significant presynaptic alterations were o...
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Functional denervation is a hallmark of aging sarcopenia as well as of muscular dystrophy. It is thought to be a major factor reducing skeletal muscle mass, particularly in the case of sarcopenia. Neuromuscular junctions (NMJs) serve as the interface between the nervous and skeletal muscular systems, and thus they may receive pathophysiological input of both pre- and post-synaptic origin. Conse...
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If such a nerve fiberwere to be directly joined to amuscle fiber of, say, 50μmin diameter, then as the propagating action potential reached the nerve–muscle junction, the local circuit current density set up in the muscle would be considerably reduced from that in the nerve. This reduction would occur because the nerve and muscle must have the same total current, a consequence of current conser...
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this thesis deals with the construction of some function algebras whose corresponding semigroup compactification are universal with respect to some properies of their enveloping semigroups. the special properties are of beigan a left zero, a left simple, a group, an inflation of the right zero, and an inflation of the rectangular band.
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2011
ISSN: 0531-5565
DOI: 10.1016/j.exger.2010.08.029